This paper serves as a summary document from the Mental Health presentation strand and Roundtable Discussion for the Interconnected Systems Framework that took place at the 2016 Positive Behavioral Interventions and Supports Leadership Forum in Rosemont, Illinois. It was developed based on input and discussion from presenters and participants at both the sessions and RDQ session. Its purpose is to share strategies to effectively implement ISF by outlining its rationale, procedures for implementation, a site implementation example, frequently asked questions about ISF, and additional resources. The authors aim to provide practitioners, leaders, and policy makers with a useful guide to implement the ISF, so as to best provide mental health services to children, families, and community members.